I like my chances against a single, average sized wolf. Sure, there are some wolves out there that are over 3' tall and running close to 150lbs, and one like that would probably make short work of me, but if some 80 pound wolf came at me out in nature and I couldn't kill it, I'd be surprised. Sure, it'd do some damage, maybe even some major damage, but unless it sneaks up while im asleep and gets a full on jugular bite, it can't kill a 6'1 230lb guy that fast.
Chances are, one would start out circling me, nipping, sizing me up, etc. Something humans are very good at. We are vertical, with a superior view of the wolf and the terrain, and we can turn around so much faster than a wolf could circle us, so the wolf would have to come straight at you, which is much much easier to defend. It is true, we aren't particularly tough or strong for our size. However, our only very weak area is our neck, which is easily defended, being that mine is much higher up than their typical prey. Much smaller relative to our size than many common prey animals. I also have powerful, highly articulate, dextrous upper limbs right up there to defend it. I have extremely powerful legs, capable of great stomping and kicking force, if able to be properly applied.
Primates are highly adept in wrestling, or rather just rolling around on the ground. Much more so than any canine, I can only imagine it'd be pretty easy to get a wolf on its back or a similar position, from which you have many ways of possibly killing the wolf. There's probably rocks around, grab one and bash their fucking skull in. They're not cows with 1/2" thick skulls, even a two inch piece of gravel could make short work of their head/snout, much less a nice brick sized rock with an edge or two on it.
No rocks? Go for their legs. Wolf legs are strong and highly optimized, but only in the front to back direction. So they can run forward fast, but otherwise, are pretty weak. Grab a leg and yank it, or really just exert it in just about any direction and you could easily hurt it pretty bad.. If you can get it on its back, grab both front legs and just push them apart as hard as you can, like pinning someone. Dislocating both front legs that violently, ripping tendon and muscle, would without a doubt end the fight immediately. Grab a hind leg, put it under your foot, and thrust. Break the shit out of that wolfs leg. Knee it in the gut repeatedly. Punch it in the kidneys repeatedly. Choke the motherfucker with your hands. Rip its asshole out with your fingers. Rip their eyes out. Ram your thumb down their gullet. Get your arms wrapped round their chest and suffocate them with a bear hug. Break their neck. PUNCH THEM IN THE FACE/SNOUT/EAR AREA REPEATEDLY.
Grab the fucker and pick it up. Particularly if you're wrestling on the ground or you can grab it by the tail/leg and dive on its back or something. Maybe you were out fishing so you're by a lake. Drown the bastard in the lake.
I see many, many ways to kill or do significant harm to a wolf under 100lbs. I see only one way for a wolf to be able to quickly kill me (neck bite), which would be nearly impossible for a single wolf to get on a human of my size. I think I could kill a wolf with my bare hands.