This is on a E8400 with Radeon 3450 running Vista 32. Yeah, for the console client, I stop it, then run it with -configonly, once I'm done, I take that out. I set the SMP client to idle, and the GPU to 'slightly higher'. The GPU client runs fine (actually faster than my E9650 rig with the same card), the SMP client on the E8400 does not run at all. Looking at the folding forums, they talk about setting some environment variables, maybe I need to try that out.