My recommendation is for you to talk to a local guru. Usually a computer nerd at the local college to get the right stuff(computer instructor who looks like a nerd) or if one is not available, the local computer store nerd (computer techie) who can rate the goodies you want.
You really don't have to spend $5000 for a good system. You can signup at the local community college to get academic software to cut your computer programs to about 70%+ off.
Next, you can make up a list and check with a local ebayer who really knows how to get great deals on eBay for 30% to 50% less than NewEgg. If you willing to ask questions on AT, you can do the same face to face in your hometown.
The bottom line, you could get a fabulous computer system about $2500/$3000. Your software can range from $1500/$2000.
It really depends on what you capable of, what your computers skills are, and what you want to accomplish.
You don't have to be a rocket scientist, to use a computer, but neither should a computer be made for a rocket scientist, to use it.