In Xarick's case, that was definitely unacceptable. Also if it's audible over everything else, it's an issue. My 7950 has whine, but it's only audible inside the case and with a few fans on, you wouldn't hear it.
Now, here's a little trick if you just suffer from mild whine during high FPS... you can use the drivers to force Vsync always! Even for those games that render 1000s of frames in menus, you're not actually pumping them out so it doesn't matter. So unless you're trying to bench for the highest fps, you can live whine-free.