citrus fruits help the liver? - hesperetin

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Titan

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Oct 15, 1999
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Most of us around here know that pure fructose increases triglycerides in the liver. I had always heard that citrus is good for cleaning out the liver, of course I'm the resident fool who just soaks up what he hears like a sponge. :) I had heard that from more holistic sources. That hot water and fresh lemon juice is a liver tonic that "tells your liver to dump". And that "all citrus" is good for cleaning out the liver. This was from a holistic doctor I heard this.

I have made some juices or teas with bottled lemon juice instead of fresh, and I can tell the difference, fresh lemon tastes - well fresher anyway. Bottled tastes dead.

I know that grapefruit specifically has a substance in it that affects the liver such that doctors will tell you if you're on certain liver medications to avoid grapefruit and grapefruit juice.

Anyway, I didn't do a lot of digging, but a quick google search for "citrus liver" revealed an article about a study I found interesting.

http://www.springerlink.com/content/x580x365g1t23065/

A certain flavonoid found in citrus fruit was given to rats in a controlled study. The flavinoid is called hesperetin. After they fed a controlled diet that increased liver triglycerides, they added 1% hesperetin to the diet and the triglycerides dropped 44%.

That's if I'm reading it right. I tried to find more info on hesperetin with google but this is not my field, plus it seems like there might not be a lot of research on it yet. Can someone help me decipher that abstract?

If this is true, it just re-affirms the point that nature isn't stupid and eating foods in their natural raw form has benefits. This is why I eat my raw organic oranges instead of orange juice. The overall philosophy of eating what we evolved to eat - makes sense. Processing and breaking food down to its core elements and reconstructing it ourselves - does not.
 
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Mar 22, 2002
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Actually, the article states that hesperetin alone does nothing to affect liver triglyceride levels. It says that orotic acid increases triglyceride levels, while orotic acid + hesperetin decreases them. Therefore the research is shows that the pairing of orotic acid and hesperetin is what's actually causing the decrease in triglyceride levels. Now you just need to find a source of orotic acid - supposedly it's a part of the vitamin B complex.
 

Titan

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Oct 15, 1999
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Actually, the article states that hesperetin alone does nothing to affect liver triglyceride levels. It says that orotic acid increases triglyceride levels, while orotic acid + hesperetin decreases them. Therefore the research is shows that the pairing of orotic acid and hesperetin is what's actually causing the decrease in triglyceride levels. Now you just need to find a source of orotic acid - supposedly it's a part of the vitamin B complex.

Right, I did notice that. I was wondering if we can infer that hesperetin along with another substance that increases triglycerides (say, fructose) would reduce the amount. Not sure how much orotic acid is in citrus.
 
Mar 22, 2002
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Right, I did notice that. I was wondering if we can infer that hesperetin along with another substance that increases triglycerides (say, fructose) would reduce the amount. Not sure how much orotic acid is in citrus.

It doesn't quite work like that in the body. You'd have to research each and every substance you were interested in because they may have different mechanisms of action. Also, you'd have to be careful about your orotic acid intake because, if you get too much of that alone, you'll increase your triglycerides and the hesperetin's action may be null.
 
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