Hey Slim,
you using a 32 or 64 bit OS? Because if it's 32 bit, soon you will be asking where the extra RAM went.
Also, what motherboard?
From reading many posts around here:
2 x 2GB is best.
4 x 1GB is good because you have a lot of ram, but sometimes is stressful for northbridge/on chip memory controllers.
3 x 1GB + 2GB? Have not seen that yet. If you have an nForce northbridge, probably won't work. As someone mentioned, all memory banks have to be set to the same timings, probably manually, since there is a good chance the timings programmed internally won't match up.
Oh, and what voltage do all these mem sticks need?
GL
NXIL