I was thinking macros are the way to go if you can translate the click to a key input....then program the function into a device like a remote or mouse button combo. I did this using macros and an opensource remote control back in the Windows 98 days.Macro Express can do that:
http://www.macros.com/
There's a lot of ways to control functionality, i.e. within specific pixels on the screen, within a specific window on a screen, etc.