- May 11, 2008
- 19,592
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That is sad to read about. Stiff person syndrome seems to be pretty rare...
Extreme muscle spasms that increase with stress.
According to literature on the internet, the muscle spams can be strong enough to even break bones. That must be the case especially for people with osteoporosis.
A few things came to mind when reading that the condition worsens under stress , it is known that cortisol affects the immune reponse, surpressing it.
That reminds of persistent infections that are kept under control by the immune system...
Some variant of latent Tetanus infection ? Some persistent verison of Clostridium tetani ?
Perhaps Clostridium tetani spores are present in the body ?
Toxoplasma Gondii cysts in the spinal cord modulating the neurons there ?
The neurotransmitter Acetylcholine is used for control of skeletal muscles. This neurotransmitter binds to receptors in the muscle and causes the muscle to contract.
An issue with Acetylcholine or neuromuscular junctions ?
How are the Acetylcholine receptors ?
Blocked ?
Or some other biological molecule is binding to the receptors ?
Or somewhere higher up in the whole brain to muscle system like for example other chemical synapses ?
Extreme muscle spasms that increase with stress.
According to literature on the internet, the muscle spams can be strong enough to even break bones. That must be the case especially for people with osteoporosis.
A few things came to mind when reading that the condition worsens under stress , it is known that cortisol affects the immune reponse, surpressing it.
That reminds of persistent infections that are kept under control by the immune system...
Some variant of latent Tetanus infection ? Some persistent verison of Clostridium tetani ?
Perhaps Clostridium tetani spores are present in the body ?
Toxoplasma Gondii cysts in the spinal cord modulating the neurons there ?
The neurotransmitter Acetylcholine is used for control of skeletal muscles. This neurotransmitter binds to receptors in the muscle and causes the muscle to contract.
An issue with Acetylcholine or neuromuscular junctions ?
How are the Acetylcholine receptors ?
Blocked ?
Or some other biological molecule is binding to the receptors ?
Or somewhere higher up in the whole brain to muscle system like for example other chemical synapses ?
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