Originally posted by: lenjack
my guess is you're using the wrong screws.
Yup.
Chances are the holes are now stripped and you'll need to use a larger screw (self-tapping variety). Another possibility is you
don't have the self-tapping variety, which are much more dificult to use in a tapping situation.
Personally I don't use self-tapping screws as I don't like how they chew-up the plastic. I use machine screws that are long enough to protrude slightly and secure them with flat washers and nuts.
Here's a tip to avoid cross-threading when reinstalling screws into previous threaded into materials: turn the screw counter-clockwise until the threads "click" into place. It should tighten easily after that (if it doesn't, you went too far and need to turn c-c until it "clicks" again)