- Apr 2, 2004
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One of the areas of study at Stanfords Foldidng@Home: Quote is from here.
Recent Research Papers can be found here.CANCER AND P53 . Half of all known cancers involve some mutation in p53, the so-called guardian of the cell. P53 is a tumor suppressor which signals for cell death if their DNA gets damaged. If these cells didn't die, their damaged DNA would lead to the strange and unusual growths found in cancer tumors and this growth would continue unchecked, until death. When p53 breaks down and does not fold correctly (or even perhaps if it doesn't fold quickly enough), then DNA damage goes unchecked and one can get cancer. We have been studying specific domains of p53 in order to predict mutations relevant in cancer and to study known cancer related mutants.
January 2005: Our first work on cancer has recently been published.
February 2005: We are expanding FAH's p53 work to other related p53 systems
July 2005:We are getting some interesting results from recent new FAH p53 projects.
October 2005: Two new sets of projects have completed and two new papers are being readied for peer reviewed publication.
November 2005: FAH researcher Dr. Lillian Chong presented her work on p53 at a lecture at the University of Pittsburgh.