Yes you can mix 10K and 15K SCSI drives.
[Edit: Just make sure they both use the same kind of connector as your SCSI controller. In most cases, this just means avoiding SCA 80-pin hard drives.]
LVD is not the issue as Goosemaster posted. LVD (low voltage differential) is a physical layer communication protocol, as is HVD (high voltage differential), and non-differential (SE - Single Ended). However, to operate at Ultra2 Wide or above one must have all LVD devices on a bus, unless there is some sort of smart-negotiation on the controller. Some of the Adaptect controllers like the 29160 (With out the N, the N version does not have it from what I've heard). However, that smart negotiation adds overhead and has to share the bus and thus still slows things down.
The 68-pin connection is generally for Wide devices, while the 50-pin connection is for narrow devices. It just happens that there are no LVD narrow protocols currently.
Ideally, one should have all devices on the channel with the hard drive as Ultra160 (LVD). If one has SCSI CD and DVD drives (which are generally narrow devices that operate at Ultra), it is best to place them on a different channel. If a 39160 is not in your budget, than getting the 29160 (non-N) is the next best thing.