Professional markets, HPC and Server are the ones that offer highest resistance to change.
When I look at professional forums, and discuss with people about the hardware, the biggest problem is the mindshare, and beliefs about... software.
Believe it or not, but People in professional market are able to equate software performance with Hardware performance. For example, CUDA gives zero abstraction level from hardware, and the application is running as close to hardware as possible - the software is extremely optimized for Nvidia, and therefore - it gives huge boost to performance. But its all due to software optimization. But Pros believe its because of Nvidia amazing hardware.
On the other hand we have had OpenCL applications, and two GPUs from two manufacturers, AMD R9 390X and GTX 980 Ti. Both GPU with similar efficiency, but AMD GPU was slightly faster. The pros were adamant that it was due to software optimized for AMD, not Nvidia. You get the picture of beliefs in this market?
It will be EXTREMELY hard for AMD to get traction in any professional market. Their brand is not considered as performance oriented, their software is not considered "quality" enough, and their marketing is absolutely atrocious. Hardware alone will not sell any even with best potential.
Steve Jobs have said many years ago, that People in enterprise markets are confused. And that lately became extremely apparent.