Depends. Are you going to want to boot from them? You'll need BIOS support then. If you just want a (non-boot/OS) fast data/scratch drive, then have at it, if you are running Win10.
Even if using as a data/scratch drive, you probably won't get full speed out of it, due to older PCI-E standards on the board(s) that you're using.
I guess, I wouldn't bother, unless you have an existing OS install that you desperately need a faster Photoshop scratch or database or VM drive, and you can't upgrade the platform.
You could investigate "booting with Clover", that might let you boot it, if you have a UEFI BIOS to start with.