"No" is hardly accurate.
You have to check out the interface to see if it is compatible with your PC (SCSI etc). I believe new macs have normal ata33 and ata66 drives in them. If they are the same interface, then it shouldn't be much different than converting a hard drive from linux/unix file systems back to fat32. Sometimes fdisk will do it, but othertimes a lowlevel format may be nessessary. After this you should have an average PC hard drive.