If you use the USB 1.1 hub you will only get USB 1.1 speed, which can be significantly slower then USB 2.0 (12mb vs. 480mb). If your USB 2.0 device has any kind of bandwidth requirements (scanner, dig cam, hard drive, burner even) then using a 2.0 hub will make a big difference, if you are talking about a keyboard, mouse or something that does not require 2.0 bandwidth but just has it to say that it is 2.0 compliant, then it wont matter.