Depends on the mainboard.
Early socket-5 mainboards don't have multiplier jumpers, which would mean you're stuck at 1.5x - for 100 MHz max. The next iteration had one jumper for 1.5x or 2.0x and stronger voltage regulation, for up to 133 MHz CPUs. Take three finally had two multiplier jumpers for up to 3.0x, and even stronger voltage regs for up to 200 MHz CPUs.
Then came the switch to socket-7, still two jumpers, and the capability to run split-voltage processors, using separate CPU core and rest-of-mainboard voltage regulators.
Regards, Peter