Heh, playing with the QuadCF right now. So far I'm having a hard time finding flash cards it likes. A-Data cards don't work, it doesn't always see them on bootup. I have one other card that works fine, but so far I can't get it to work with a single CF card. Waiting for more cards to do more testing. I did get it working with 4x4GB A-Data, but it was not bootable with those cards. Speeds are PCI limited, and don't get better with more than two cards. It's basically an IDE RAID card with CF slots. Still with 2x4GB cards in RAID it managed ~60MB/s, 58MB/s with four in RAID.
I prefer using the CF-IDE adapter types, easier to swap in another card for more space or better performance.
No real preference in the CF-IDE adapters, they're all pretty much the same. All they do is convert the connector, CF-ATA cards have a built-in IDE interface.
Quite a few mini-ITX boards have CF slots, but I'm not sure if any of the Via-built boards do. I usually see them as an option on the boards from the embedded manufacturers(Kontron, Commell, Ibase, Itox...)