my mom drove a dodge caravan for 195k miles, the only major overhaul it ever needed was a transmission at 125k or 150k miles.
i'm personally riding around in a ford focus with 170k+ miles on it... the clutch needed to be replaced before 100k, but not by much.
i dunno. it's all anecdotal. i've never seen any hard facts about 100K+ mileage reliability of domestic cars in the last 10 years, but I'm a graduate student (meaning I'm poor, and my friends are poor as well, hehe) so I do have lots of friends driving domestic cars with 100K+ miles on them, and it's just a completely different story than in high school, where my same group of friends were driving around in high-mileage domestic cars from the 80s
edit: and needing lots of repairs on those cars.