Best weapons in games

[NAC]

I'm old school.
Nothing ever gave me more shooting pleasure than the DOOM shotgun & double barreled shot gun.

Oh... one thing did, but it ain't a gun: the chainsaw and a room full of pink demons.

 

[Teknic]

Shogo - Rocket launcher while in mech form. Or the silenced submachine gun while on foot.

 

[stahlhart]

The double barrel coach gun in Serious Sam, the crossbow in HL2, the alt-fire grenade from the flak cannon in UT.

 

[gothamhunter]

I'm old school.
Nothing ever gave me more shooting pleasure than the DOOM shotgun & double barreled shot gun.

Oh... one thing did, but it ain't a gun: the chainsaw and a room full of pink demons.

Which is why it says best weapon and not best gun

 

[LurkerPrime]

Blaster rifle (blaster bomb) in x-com and its equivelent in TFTD.

edit:
also megaman's gun.

 

[Rezident]

Favourite: Gauss Gun (half-life) also loved the laser-guided rocket launcher.

Snarks were also pretty cool, but the best weapon I have used is The Spy's sneakiest weapon in Team Fortress 2: invisibility.

 

[AstroManLuca]

Oh yeah, Fallout 2's .44 Magnum Revolver was pretty awesome. Get the right perks and you could just about unload the whole thing in one turn.

Fallout 3 had Lincoln's Repeater, which was a great gun as well, but it didn't feel as special because the ammo for it was so rare.

Speaking of Fallout, a fully upgraded Turbo Plasma Rifle was pretty much king of weapons in the first game.