Start by having a licensed electrician inspect the homes wiring and grounding. Make a list of everything that connects to the home, water, telephone, cable, fios, power lines and make sure all those connections are as they should be. Lightning will use one of those to enter the home. If the home has its ground on the water pipes that is no longer allowed as acceptable grounding points. The reason is pipes loosen, are replaced with pvc and can no longer be guaranteed to be at ground potential like they were 60 years ago when everything was steel or cast iron or copper. If your line is using the piping for ground make sure that piping is still tied to the ground outside the home and not corroded. One downside of using copper for grounding is that it acts as an electrode and it can cause the pipe to corrode and leak. There should only be 1 ground point on the home. Sometimes cable or telephone workers will install a second ground point and that causes ground loops.
Install a whole house surge protector. They cost about $100 and install in the service panel and protect the line as it comes into the home. There should also be a protector on every line connected to the home from the phone company, the cable company, etc. Install these at the point the line connects to the home. All these connections should have a ground wire going back to the homes 1 ground point. For the hardware use a quality online UPS if you can afford it. They are not cheap, averaging $500 to get started but offer the greatest protection.
cliffs:
Inspect homes wiring
Install whole house protector
Install protection on all externally connected lines
Use online UPS.