My vote would be a pyramid 3-1 setup. Take the 27" and 2x of the 22" monitors and place them on the bottom row. Then take the last 22" monitor and put that somewhere along the top of the monitors.
This would require either a custom monitor mount (not sure how extreme or what kind of budget you're looking at) or you can tier them so they will fit. Otherwise you will have one w-i-d-e span to look around with all four monitors in the same "row".