- Jan 29, 2005
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So these are some of the more notable comedy duos in movies that I can come up with. Each pair has their own comedic chemistry that makes them more funny together then apart, but to me it doesn't get much better than Walter Matthau and Jack Lemmon. They did it great early in their careers together, then did it even better as time marched on. Farley/Spade may be my favorite, and Wilder/Pryor may have the best chemistry in my opinion, but Matthau and Lemmon are the "best" duo in the last 50 years, hands down.