Even though I use S3 24/7 I shut my systems off when I go to a trip. Power outage can do funny things when you're asleep.
With hybrid sleep the session is saved to disk, so a power outage doesn't seriously affect your stuff.
I typically use sleep mode at the end of each day on my desktop PC, so I can just press a button and it is ready to use in about 5 seconds.
One thing I would advise however is that Windows will sometimes wake the computer in the small hours to install updates and then shut down, so leaving something open/running when the computer goes to sleep can be perilous. I typically close all programs before putting my computer in to sleep mode overnight because of this.
I've resumed Windows (it was in hybrid sleep) after a power outage. The computer resumed as if it was in hibernation, the only weird thing was that it was quite sluggish for about 10 minutes after resuming (and this doesn't normally happen for me if I intentionally hibernate the computer, so my guess is that hybrid sleep saves only absolutely necessary data from mem to disk and skips cached data).