First off, this thread is just for discussing mfenn's mid-range build - for other queries make a new thread. Do you need ECC RAM? If so you need a Supermicro X79 workstation board and a Xeon E5-1600 or E5-2600 series CPU. If not, any consumer X79 board with 8 DIMM slots will do, plus an i7-3820 or better. i5's are out since they're for LGA1155 which doesn't support more than 32GB of RAM. As for the video card, what are inputs do your monitors have?