First of all a huge ship like the Titanic does not pitch and roll in rough seas like a much smaller ship would. So no problems with sea sickness.
Second of all, rough seas were a non factor on the night the Titanic hit the iceberg. Instead the problem was a thick fog and calm seas. And strong winds would have simply blown the fog away greatly increasing visibility.
And I recently read that very strongly lunar tides and greatly increased the calving of icebergs in the Titanic chosen course. That and the fact the rivets in the Titanic hull were made of cold short very high sulfur content steel. That plus the fact existing naval regulations failed to require enough lifeboat space for even 50% of the passengers and crew. As any human immersed in water that cold had a life expectancy of only 90 seconds or so due to hypothermia.
Could a replication of the Titanic happen today? I would like to say no, but when you look at the various recent cruise ships accidents, a combination of Murphy's law and idiot ship Captains, its hard to say never.