I understand the static part, but what does "buffer up" mean?
With my previous system, I was using a Seagate Barracuda drive and nforce2 with Soundstorm audio, and never noticed any problems. When I switched to a new Hitachi drive early this year, I started getting static over the speakers, noticeable mainly when there was significant hard drive activity since it was sustained then. It was kinda fun in a way, "listening" to the hard drive reads and writes.
Did your problem just start or has it always been that way? It is in all likelihood a hardware issue, something is causing interference, but it could also be a driver issue. You might be able to resolve it by moving the sound card to a different slot.