This seems to be a little annoying problem, and I'm not too sure if it is motherboard related or what. I just can't seem to get my mouse working in Safe Mode or DOS. It works in Windows98SE though. This is Microsoft Intellieye Optical, which is connected to PS/2 port. Another thing I notice is that it says "Input Device: NA" upon boot up and after all my cards are detected. Is there a setting there or anything which will make this combo to work ?