If you're not going to overclock or do anything hardware enthusiasty, then Intel boards are nice. I have one (D850MVL - I had to go RDRAM since that and PC133 was the only thing available in December...), and it's utterly rock solid. Can stay up for weeks unless WinXP flakes out from overload (I can abuse an OS quite nicely), etc.
Intel has nice Windoze-based BIOS upgrading , works very nicely. Their docs are good, too... and the boards come with a decent software bundle, IIRC. Norton Internet Security (incl. NAV) and a bunch of other stuff... (I don't remember the details, I didn't install it because I have SystemWorks 2002) Pretty monitoring utilities, too. Looks very polished.
Now, if you want tweaking features, etc, forgot it. There are none. The Intel boards are "by the book"-type boards; don't expect to get away with not having the 12V P4 connector on your power supply, for example. Intel makes them stable by being strict about everything. (You'll possibly get less DIMM slots on the DDR boards than with other brands... but the Intel board _will_ likely be stable with all slots filled)
Also, the onboard audio is probably not that great at all... (I never used the audio on mine, but I have another board with that SoundMAX stuff, and it sucks majorly. maybe they improved it since that i810 board was made, but I wouldn't bet on it too much) Get an Audigy or similar, VERY nice sound card.
I might add that I've had a few friends use Intel boards too, they never had any problems with them. Deathly stable, gets the job done, works with everything they've tried...