You shouldn't have a problem with the vast majority. the problems that people run into with ATX case and ATX board usually are placement of the various components of the board and case. For instance, most mid towers will have the drive bays for the floppy and hard drives over the memory. this doesn't cause a big problem, but you will have to remove the drive bay or hard drives to get to the memory. The biggest problem would be as said earlier....an atx board would NOT work in a micro atx case. I believe there are only support for 4 expansion slots in the rear in the Micro vs. 7 for the ATX. I would add into the mix that power supplies vary in quality. AMD systems tend to be more strict on the power supplies. The good thing is...Enlight makes fairly good cases (definately worth the money). I have used to Enlight cases, and I have found them to be nothing but a good case at a fair value. The case should actually come with markings in the case to show you where the screws should be placed for an ATX board.