For desktop use? Absolutely.
To get straight to the point, there are two fundamental truths in GUI design:
1) The common monitor is 96dpi
2) The "sweet spot" for how far back a user should be sitting to viewing such a monitor is 20"-28"
This leads to a problem: most GUI elements are designed around those assumptions. A button, for example, should look a certain size on a 96dpi monitor at 20"-28" back.
Worse, no modern OS can properly scale an entire screen. Win7 can do DPI scaling of text easily enough, but anything bitmapped (such as the aforementioned button) will always be the same dimensions as defined in pixels.
So why is this a problem for a 30" monitor? As monitors have grown resolution, they've simultaneously grown in physical size to maintain the same 96dpi (give or take a few pixels). In 1995 you were sitting 20"-28" from your 15" 1024x768 CRT, in 2005 you were sitting 20"-28" from your 20" 1680x1050 LCD, and in 2010 you're sitting 20"-28" from your 30" 2560x1600 LCD.
With every expansion in physical size, the amount of your direct field of vision occupied by your monitor has increased. This is not immediately a bad thing, but with a fixed DPI and fixed viewing distance it means that there's a finite limit - you can only see so much.
From my own experience, I consider a 24" monitor to be a limit. On a 30" monitor there's simply too much - I can't see the entire screen in my direct field of vision without having to dart my eyes around by a significant degree. The Win7 orb is all the way in the bottom left-hand corner, while the Close button is all the way in the top right.
For desktop use this is unmanageable. All of the extra resolution isn't making my experience any better because it's more than I can see. It's not like the "real world" where the object of my focus is in a very narrow spot in front of me - every bit of text on the screen has value and I need to be able to read it.
Now I could move the monitor back, but this has the impact of breaking the 96dpi/20"-28" rule listed above. I can now see the entirety of the monitor, but all fixed-resolution assets (basically any bitmapped images) are the same dimension since OS DPI scaling only scales text and vector images. Or in other words, if I sit back farther I can't read images.
So yes, for desktop use 30" is too big. In fact for desktop use I'd consider monitors outright stagnant: you can't make them physically bigger because they'll be outside of the user's FOV, and you can't increase the pixel density because they won't be able to properly see fixed-resolution assets. Until we're in an all-vector world where everyone can size images and text to their needs, the 24" 96dpi monitor is king.
However this only applies to desktop use. For movies, gaming, and really anything where you don't need to read text, a 30" monitor is fine. In those situations objects being outside of your FOV are not a major issue, and may in fact be intentional.