Well, I tried it. It surprisingly did not feel odd. Most likely because you still use the same fingers for fire and alt fire. Although it didn't feel odd, it took a bit of getting used to. I surprisingly kicked butt in a few games of BF2142. In that game I'm a sniping fool. Although I did okay with it, it was a bit more difficult to line up your sight with the target. Definitely more suitable for infantry fighting. I also lowered the resolution big-time for sniping. I was a little disappointed to find it is powered with an optical sensor rather than a laser.
Overall, I was impressed with this product. For some people, this may be just what the doctor ordered. Relatively easy to use and get used to. Not very good for precise aiming. Unfortunately, it can sometimes be difficult to teach an old dog new tricks. I'm sticking with my Logitech G9.