Efficency doesn't really matter here. The spec'ed wattage is NOT delivered to the load, but what is disapated by the amp so the straight numbers should be pretty good. All stereo amps have to be class A, that is the class which gives accurate reproduction of the input signal, class D runs at off or saturation.
Yes most electronics are designed with a safety factor, what is it? I am not sure, it's your amp you look for the limits.
The final answer is that fuses should have no effect on power, unless you are drawing enough current to be over the rated output, again it is your amp.