Uhh, I wouldn't do that. Not unless you have an AGP Pro card. That is what it is there for; to keep other cards (non AGP Pro) in place and keep them from moving about when you move the system. IF you remove it, it will not go back in. Disclaimer: There are some who have removed this and had no real problem. As long as you don't move the system around alot you might be OK. I really don't know for sure as I have not tried it. To be on the safe side, just blow around it with the canned air to get the dust and leave it in place.