Definitely not the overclock. I know some people were saying the game didn't like sli so I disabled it, and it actually seems to run better (solid 60 fps) since but I'm not sure if that's due to using 1 card or because I had accidentally recorded 60gb of video from fraps before that time as well. Still crashes a lot though. If it were the overclock I'd be having blue screens, memory dumps, and problems with other intensive games/programs, which I'm not/haven't since i overclocked ~4 months ago. I've updated my video drivers as well with no effect. The game does crash occasionally on my second pc, but its like once every 10 hours on that pc and once every 45 minutes on mine.
Unless Sacred 2 is doing something to my cpu that occt, prime95, crysis + expansion, l4d, aoe3, bf2142, TQ, D2, EE, wc3, ut3, supcom + fa, ra3, etc are not doing, I think its safe to say its not the overclock thats the problem.