The hub wouldn't be because of the increased cable length required, it would be for ease of access. If you don't regularly plug/unplug usb peripherals, or change monitors, etc., then the added hassle of accessing both the front and back ports of your pc may not bother you too much. Just need to set everything up from the beginning. I guess it also depends on how large your desk is. But the thought of, for example, plugging in a usb drive into something mounted behind my desk, or a gamepad, made me quickly dismiss that idea.
Also, the idea of displaying my PC's internals just doesn't appeal to me. I had a case with tempered side window and internal LEDs, and it did nothing for me. The only use was being able to keep an eye on the coolant level in the reservoir. Otherwise IMO its a waste of time. But hey, everyone's different. If you like it, then go for it.