I have done that, and it worked. Also had no problem with an old (built like a MAck truck!) ScanJet IIcx (SCSI External.) The 5300C was hooked to USB. The procedure is:
1. Install the latest Deskscan software for your scanner BEFORE attempting to do anything with it - don't even hook it up.
2. Reboot and when all is up and running, hot plug the scanner into a USB port. New equipment will be found, and the drivers should be installed by XP.