I'm using it with windows Me - and its needed too.
Just as in 98, vcache still loves swiping all your ram in 'Me'. You would think microsoft might have solved this problem or at least added some program to control it with the Win me release.
If anything Win Me is worse - it not only eats ram, but resources take a beating too. You will head into the 50s and under after running a few progams - even with system restore disabled resource usage seems to drop far quicker than in 98.