I'm not sure popularity was a factor, ASUS didn't exactly position it to become popular.
ASUS chose the low-end K8M800 for the first motherboard (A8V-MX) to showcase VIA's long-awaited high performance Southbridge, when VIA's 'premium' K8T800 Pro, K8T890, and PT880 Pro were readily available. And not even a full-featured ATX motherboard with some bells and whistles, either, but a MicroATX board with your typical entry-level "All-in-One" feature set.
Over the next several months, ASUS released the following models using the VT8251, most of which were equally out-of-place or awkward (release dates are approx. based on the first release BIOS or the oldest BIOS listed on ASUS download pages):
P5V800-MX LGA775 P4M800 AGP (September 2005)
P5VDC-MX LGA775 P4M800 Pro AGP (October 2005)
A8V-VM S939 K8M890 PCI-E (January 2006)
A8V-XE S939 K8T890 PCI-E (February 2006)
K8V-XE S754 K8T890 PCI-E (March 2006)
A8V-X S939 K8T800 Pro AGP (April 2006)
P5V800-MX, A8V-VM, and P5VDC-MX followed the same pattern as the A8V-MX in being entry-level mATX boards with integrated graphics. The only models that could remotely be classed as 'premium' motherboards are the A8V-XE, K8V-XE, A8V-X.
The K8V-XE would have been an attractive board...had it been released 18 months earlier when Socket 754 was still dominant. The A8V-X was S939 but used the K8T800 Pro that had been shipping since June 2004! The A8V-XE was the only that was appropriate as a premium board for its time (S939 with PCI Express).
Only the P5VDC-MX and A8V-XE can readily be found in stock (e.g. Newegg), the others have not been readily available for some months now, suggesting ASUS decided to rapidly cycle them out.
How much interest could the VT8251 generate on entry-level or retro boards that aren't likely to be purchased by those wanting its newer features?