Multipliers are downward unlocked and upward locked. Only the Extreme series is fully unlocked. The default multi on the E6750 is 8x, so that means you'll have access to 6x, 7x, and 8x. With that chip however, you'll find the most productive multi to be the default 8x with a FSB hopefully in the 400 - 450ish range.
Yes, the best air coolers are pretty big -- that's the en vogue thing right now. Don't worry about the weight when upright -- your mobo can handle it plus the heavy coolers come with backplates. Takes a lot to break a multi layered PCB, though some people have noted a slight bowing with the very heavy TR Ultra 120.
For something a bit smaller, try the Scythe Andy or even the new Thermalright Ultima 90 which got great review by AT right here about 2 wks ago - just search for it. And take a look at the Scaling of Cooling Performance chart within that article. Compares pretty much every cooler AT has reviewed in past 1+ year with temps at idle and OCed. But...be sure to add 3-4C to the temps you see there...the guys at AT have one of the best (cherry picked by Intel) CPUs out there.
Personally, I wouldn't go over 1.5v Vcore, nor much above 60C load under Orthos stability testing when OCing. For 3.3ghz, you may need 1 bump in NB & SB voltage in addition to 1-3 bumps in vcore. These chips go quite far on stock volts though. Don't give it any more than you need.
Edit: Almost forgot...how's your PSU? What brand/model are you using? Corsair, Seasonic, PC P&C are good. Be careful with Antec.