Originally posted by: bUnMaNGo
Originally posted by: phatcow
so avoid whatever the coast highway is?
have you ever driven on PCH? Sure, it's a nice view, but the majority of it up on the central coast is part of some national forest (I forget the name of it). That means more twisties and turns than a Twizzler

I made the drive from SF down the scenic route, past Half Moon Bay, through Santa Cruz and Monterey... down to San Simeon, San Luis Obispo, Pismo Beach, and finally, Santa Barbara. After that, my friend couldn't take the drive anymore, so we hopped on the 101 and cruised into downtown LA. Don't get me wrong- it's definately worth a drive, but maybe just once or twice. Took us about 10 hours to drive down to LA from San Francisco down PCH. I plan on making the drive again one day when I have time to take a week off of everything and spend some time in each of the cities we pass. So, to answer your question, I'd just take the 5 all the way up from SD... should take about 5-6 hours if you don't get caught speeding. My personal record? 4.5 hours from San Jose to LA. That was taking the 101 -> 152 -> 5. To get from SD to downtown SF, you'd want to take the 5 to the 580 to the 80, which leads you right to the Bay Bridge into downtown. Or, you can take the semi-scenic route up the 101 from LA, which will drop you right by the airport up in SF.
On another note, why drive? Southwest is running a bunch of specials, and if you can plan it correctly, you can get a flight roundtrip to Oakland (which is just across the Bay Bridge, you can take BART into "the city") for around $70/person.