Your power supply is probably vibrating against your case, causing the hum. try removing it from the case, and plug it into the wall, without being hooked up to anything and see if it still hums. (Using the ATX PS trick)
If it doesn't hum, it's vibrating against the case.
This can be solved in a couple of different ways, make sure it is secured in the case well, get the screws tight and jiggle it a bit to see if it moves at all. (it shouldn't.)
you can try and put rubber washers in between the Case and the PSU
you can also put a small piece of padding (usually a piece of cardboard or foam works) under the PSU, so there are no vibrations in the spot where is rests.
If its not vibrations, call Antec and get a replacement, because there is probably a problem with the PSU, and it *may* lead to damage to your system. Antec is a wonderful and reputable company and should gladly replace it.
As for the HD issue, how old are they? They might be going bad, in which case you should find that out quick, so you can replace them without losing data.