while you have gotten quite a bit of help already, Id like to spin it in a slightly different direction...
Is the "looks" of the speakers important to you? Size of speakers, wood finish vs. vinyl vs. flat black vs. piano black, stand mount vs floorstanding? There is no question that within the 1k-2k region, the speakers will last for years. Electronics do get phased out over time (different dolby processing techniques etc), but the speakers (i have found) that are beyond 150$ per pair really start to have good craftsmanship built into the units.
Is surround sound important to you? (surround takes more "work" to setup "properly" and to fish wire around or hide the wires). Would a good pair of front speakers with a good center speaker appeal to you -- or would you find that unacceptable compared to having a full 5.1+ setup?
Would you use the system more for music or more for movies? (or balanced between both?)
How large is the room (17x15x?) that your system will go in, and is it sealed or open to other rooms (this determines the power of the amps and the size/number of subwoofers "required")?
And finally (for now), here is the question you may not like. Do you know what kind of sound you want? Have you auditioned speakers from local dealers of name brands such as klipsch, jbl, paradigm, b&w, monitor, etc.?
This final question is only important if you feel that you want to move to a system that is "the next step" beyond home theater in a box (HTIB) sets. If you enjoy speakers that make you feel like you are sitting front row vs. sitting in the middle of the concert hall, that is good information as well.
For an idea of what you might expect when moving from HTIB to separate speakers in terms of finish, here is an
example.
Overall, if you want to buy "something and be done with it" HTIB like the one Yoyo recommended is a great choice. If you don't mind getting more involved with this, then perhaps you may want to consider separate internet direct speakers (they come with 30 day money back guarantee). In addition to (my experience) awesome customer service and support, these companies tend to take in less markup and instead put the money into more beautiful finishes (might be important to you) and better quality parts overall.