When someone says "That guy's got game", it can mean he has skill, talent, or ability.
If a girl says that guy "is" game, it could mean he is available, single/looking, or a possibility.
If a girl says that guy "has" game, probably means he has qualities such as suave, attractive, equipt, experienced, or charm. If a girl tells her girlfriend that you have game, I am pretty sure that can only be a good thing.
Having game is good, not having game bad... an easy way to look at it.