I haven't tried Fusion but did play with Overdrive, and it's like a poor man's lobs.. or Turbo Boost. As for Overdrive, it lets you assign processor affinity, multipliers per core, and vCore on-the-fly. Imagine NV's control panel and replace the AA, AF, etc. with those and you get the idea.
If you look closely you can see it has assigned 3 cores for GRID at +1 multipliers. Interestingly it lowers the unused core's multi by -3. You have to be careful with AMD's profiles because I saw it raising the multi by +2. If you've already overclocked your CPU to the limit, that will obviously cause trouble. And overall I felt it was not polished enough and didn't bother with it for long.
On the other hand, the ability to assign affinity can definitely come in handy. I suggest to ignore AMD's profiles and try creating custom rules and see how it works.