I use WinME as a test OS to try out new software and drivers before I install their Win2K counterparts on my "production" OS. I was also an official beta tester for WinME (and MS has kept me on with the WindowsUpdate beta), so I've never had any real problems with WinME ... naturally. ;P Well, there was that one nasty bug with ATi and multiple video cards.
-SUO