Yes, the remotes tend to "work," but not as designed. Press a button...it may respond? ...nowish? That's the issue.
I've always thought the issue when a remote doesn't get reliable response is mostly because it doesn't put out sufficient IR radiation for your device to pick up the signal. You know the cliche you see on TV of someone holding their remote at arm's length, pointing at their TV? Yeah, that, presumably because they've had lots of experiences with the TV not responding.
I have a 4K optical disc player in this room and it's like that. Very iffy and I doubt that putting alkalines in the remote would improve the very often frustrating performance. I should try. But my solution is to reach for my Harmony universal remote instead. I have Eneloops in that too, but never an issue... it puts out a LOT more intense signal than the Magnavox remote, which is a joke. I have similar success using my MX-900 and MX-700 universal remotes, which have 4 Eneloop AAAs in them. POWERFUL beam remotes. I don't have to think about pointing directly, they blast in a pretty wide beam.
Edit: Thing is, if a device asks for a lot of juice from an Eneloop, it delivers. So, if there's a decent charge on it, it should not be an issue. I test the voltage using either a multimeter or one of my La Crosse chargers. When it drops below 1.2 volts it's starting to be iffy. But the voltage does stay above that for a long time in the cell depletion curve.