but the weight will have an effect once you throw hills into the equation, and of course there's acceleration as you mentioned.
Only a minor effect, unless your car is so slippery and heavy, or the slope so extreme, that you will have to downhill-brake, because engine braking is insufficient. At 80mph as cruising speed, this is rather unlikely.
So while yes, you consume more going up, you consume less going down again, which usually more or less equals out the loss, if the engine doesn't get forced into a very inefficient mode due to the elevated torque requirements.
As for
Are today's cars still built with the "national" 55mph speed limit in mind?
No, they are tuned for EPA testing, to give the best possible result in that test. Everything else is moot.
Especially with small turbocharged engines, you have to be careful with the official numbers, as often times, once you exceed a certain speed, the turbo kicks in and fuel consumption increases rapidly. The goal for a manufacturer is to have the turbo boosting minimally in an EPA cycle, but give you plenty of power if you test drive it.
The only thing that's more skewed is hybrid mpg, where they allow the battery to run out. I guess that has some validity for plug-in hybrids (but the amount of battery charge required should still be listed), but for "conventional" hybrids this is also being done, and is, quite frankly, cheating.