I tested XPwin64 beta recently on my turion laptop. Everything went reasonably well but I could not find a sound driver or a print driver for my system. I couldn't live without either so I went back to XPwin32. If I had to do it over again, I would collect all the win64 drivers unique to your system (sound, video, etc) before I started the upgrade and burn them to a CD.

PlanetAMD64 forum is a good source for a lot of driver info.
The F@H 32bit client does run on win64 but very little to no improvement in speed (not suprising)
If you go to the F@H forum and search for win64, there are interesting discussions. According to Vijay Pande (Stanford U; leader and founder of F@H), they have no plans for 64bit clients because in his words:
"Keep in mind that 64bit is only for integers. It has nothing to do with floating point, which FAH spends most of its time doing."
I guess you need to find a project with a 64bit client that spends a significant amount of time integer processing?