Nope, for the simple reason that 3.5" drives offer more storage than 2.5"s ever could. The 5.25" Bigfoot was created as a cost saving line (lower rpm, etc.) while offering about the same amount of storage.
At the time a friend was buying a new system ('97 i think), the bigfoot offered 50% more capacity for the same price of the existing drives on offer.
in todays terms, I think people would still look at getting 5TB drives for the price of a 3TB green, or a 6TB for the price of a 4TB.
There could still be a possible market for them.
Though IIRC the bigfoots where still only a 1/2 height 5 1/4" unit, so a full 5 1/4 bay design should get to 10tb without issues I would think.
I can only dream. That way, 15 years later we can sit back and smile at the 10TB bigfoot2s.