If you are refering to the two different speeds of mem that your rig shows, then yes. the 2100 will slow down the 2400 slightly. Your max capabilities should be controlled by the dimm with the least capabilities. ie speed, and BIOS options. You should try the 2100 in the first slot first as the operating system will be smoother if it is configed for the slower speed and extentions that this dimm will support. You would lose the extras of the 2400, if it indeed has any, but overall system performance should be better. This is most often the case, though not always, as variables of DDR are quite similar from one to the next.
This was always the case for SDRAM.
Try both ways and run some benches. Write down the Bios options available for each mem in slot 1. They may all be the same options, But performance might vary drastically. Test Test Test.
LOL
